ADDITION OF MULBERRY LEAF (MORUS ALBA L.) TO A DIET FORMULA IMPEDED ITS HYPOGLYCEMIC EFFECT AND EXACERBATED DYSLIPIDEMIA IN HIGH-FRUCTOSE- AND HIGH-FAT-INDUCED CD-1 MICE

Xiaoxuan Guo; Jia Liu; Hongjuan Zhang; Baoping Ji; Feng Zhou

doi:10.9755/ejfa.2017-05-1067

Authors

Xiaoxuan Guo 1 Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, People’s Republic of China
Jia Liu 1 Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, People’s Republic of China
Hongjuan Zhang Beijing Ribio Biotech Co., Ltd., No. 7 Feng Hui Zhong Road, Beijing 100094, People’s Republic of China
Baoping Ji Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, People’s Republic of China
Feng Zhou Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, People’s Republic of China

DOI:

https://doi.org/10.9755/ejfa.2017-05-1067

Keywords:

dyslipidemia, glucose regulation, insulin resistance, mulberry leaf

Abstract

Backgrounds: Morus alba L. (mulberry leaf) is frequently used for therapeutic purposes in China. This study investigated the hypoglycemic and hypolipidemic effects of a reported antidiabetic herbal formula (PLCP) supplemented with mulberry leaves (MPLCP) in high-fructose- and high-fat- (HFF) fed mice. Methods: Six-week-old CD-1 male mice were fed on normal standard diet for 10 weeks. Fat emulsion with or without aqueous/ethanol extracts of PLCP/MPLCP was administrated by gavage daily for HFF groups. The normal group only received vehicle. 15% Fructose drinking water was supplied for HFF groups. Results: MPLCP was less effective than PLCP in hypoglycemic effect. The addition of mulberry leaves impeded not only the decrease in insulin resistance and serum free fatty acid content but also the increase in spleen index. The ethanol extract of MPLCP caused remarkable increase in low-density lipoprotein levels (p < 0.01) and significant increase in total cholesterol level (p < 0.05) compared with model group. Thus the effect of MPLCP was detrimental to abnormal serum lipid levels. Conclusion: The addition of mulberry leaves to PLCP weakened the hypoglycemic effects of the original formula and exacerbated dyslipidemia.