The antioxidant activity of date seed: preliminary results of a preclinical in vivo study

  • Fatima Theyab Al meqbaali Department of Nutrition & Health, College of Food & Agriculture, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Hosam Habib Department of Nutrition & Health, College of Food & Agriculture, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Aws Othman Department of Pediatrics, College of Medicine & Health Sciences, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Saeda Al-Marzooqi Department of Pathology, College of Medicine & Health Sciences, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Alia Al-Bawardi Department of Pathology, College of Medicine & Health Sciences, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Javed Yasin Pathan Department of Internal Medicine, College of Medicine & Health Sciences, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Serene Hilary Department of Nutrition & Health, College of Food & Agriculture, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Usama Souka Department of Nutrition & Health, College of Food & Agriculture, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Suleiman Al-Hammadi Department of Pediatrics, College of Medicine & Health Sciences, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Wissam Ibrahim Department of Nutrition & Health, College of Food & Agriculture, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates
  • Carine Platat Department of Nutrition & Health, College of Food & Agriculture, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates

Abstract

Chronic diseases (diabetes, cardiovascular diseases and cancer), are by far the leading causes of mortality and morbidity worldwide. Oxidative stress is one of the underlying mechanism in the development and enhancement of chronic diseases. Polyphenols are particularly abundant in date seeds and can contribute in the progress of chronic diseases due to antioxidant properties. The present work studies the effects of date seeds and examines the oxidative stress status on serum and organs of Male Wistar rats after feeding them with basal diet comprising 0, 2, 4 or 8 g/kg date seed powder (DSP) for a period of 13 weeks. Isonitrogenous and isocaloric diets were subjected to all the four groups. Antioxidant status, protein and lipid oxidative biomarkers were measured in the serum and organs and histopathology was done. The results showed that DSP suggestively (P < 0.05) elevated the antioxidant defense system of the serum and organs. DSP decreased protein and lipid oxidative damages in the liver, muscle and brain. In addition, DSP did not alter the organs’ function based on the analysis of biochemical markers. The results indicate that oxidative stress-related diseases could be possibly prevented by the DSP bioactive antioxidants.

Keywords: Antioxidant; Chronic diseases; Date seed powder; Oxidative damages; Polyphenols

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Al meqbaali, F., H. Habib, A. Othman, S. Al-Marzooqi, A. Al-Bawardi, J. Pathan, S. Hilary, U. Souka, S. Al-Hammadi, W. Ibrahim, and C. Platat. “The Antioxidant Activity of Date Seed: Preliminary Results of a Preclinical in Vivo Study”. Emirates Journal of Food and Agriculture, Vol. 29, no. 11, Nov. 2017, pp. 822-3, doi:https://doi.org/10.9755/ejfa.2017.v29.i11.1477. Accessed 15 Aug. 2020.
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