CARDIOVASCULAR EFFECTS OF TWO AMIDES (PIPERINE AND PIPERDARDINE)ISOLATED FROM PIPER TUBERCULATUM JACQ.

Authors

  • João X. de Araújo-Júnior Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970,Maceio, Alagoas, Brazil; 2 School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Federal University of Alagoas, 57072-900, Maceio, Alagoas, Brazil; 3 Institute of Biological Sciences and Health, Laboratory of Pharmacology and Immunity, Federal University of Alagoas, 57020-720, Maceio, Alagoas, Brazil; 4 Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-970, João Pessoa, Paraíba, Brazi
  • João X. de Araújo-Júnior Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970,Maceio, Alagoas, Brazil; 2 School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Federal University of Alagoas, 57072-900, Maceio, Alagoas, Brazil; 3 Institute of Biological Sciences and Health, Laboratory of Pharmacology and Immunity, Federal University of Alagoas, 57020-720, Maceio, Alagoas, Brazil; 4 Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-970, João Pessoa, Paraíba, Brazi
  • Êurica Adélia N. Ribeiro Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970, Maceio, Alagoas, Brazil; 2 School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Federal University of Alagoas, 57072-900, Maceio, Alagoas, Brazil; 3 Institute of Biological Sciences and Health, Laboratory of Pharmacology and Immunity, Federal University of Alagoas, 57020-720, Maceio, Alagoas, Brazil; 4 Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-970, João Pessoa, Paraíba, Brazi
  • Sâmia Andrícia S. da Silva Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970, Maceio, Alagoas, Brazil; 2 School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Federal University of Alagoas, 57072-900, Maceio, Alagoas, Brazil; 3 Institute of Biological Sciences and Health, Laboratory of Pharmacology and Immunity, Federal University of Alagoas, 57020-720, Maceio, Alagoas, Brazil; 4 Laboratory of PharmaceuticalTechnology, Federal University of Paraíba, 58051-970, João Pessoa, Paraíba, Brazi
  • Cintia Danieli F. da Costa Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970,B Maceio, Alagoas, Brazil; 2 School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Federal University of Alagoas, 57072-900, Maceio, Alagoas, Brazil; 3 Institute of Biological Sciences and Health, Laboratory of Pharmacology and Immunity, Federal University of Alagoas, 57020-720, Maceio, Alagoas, Brazil; 4 Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-970, João Pessoa, Paraíba, Brazi
  • Magna Suzana Alexandre-Moreira Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970, Maceio, Alagoas, Brazil; 2 School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Federal University of Alagoas, 57072-900, Maceio, Alagoas, Brazil; 3 Institute of Biological Sciences and Health, Laboratory of Pharmacology and Immunity, Federal University of Alagoas, 57020-720, Maceio, Alagoas, Brazil; 4 Laboratory of PharmaTechnology, Federal University of Paraíba, 58051-970, João Pessoa, Paraíba, Brazi
  • Bárbara V. O. Santos Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970, Maceio, Alagoas, Brazil; 2 School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Federal University of Alagoas, 57072-900, Maceio, Alagoas, Brazil; 3 Institute of Biological Sciences and Health, Laboratory of Pharmacology and Immunity, Federal University of Alagoas, 57020-720, Maceio, Alagoas, Brazil; 4 Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-970, João Pessoa, Paraíba, Brazi

Keywords:

Cardiovascular activity, piperdardine, piperine, wistar rats

Abstract

Cardiovascular activity of the fraction from the plant Piper tuberculatum, containing two amides, piperine and piperdardine (PTPP) was evaluated in this work. Intravenous injection of PTPP (1.5; 2.5 and 5.0 mg/kg, i.v.) in normotensive rats reduced the diastolic blood pressure (DBP) and heart hate (HR) in a dose dependent manner. This effect was affected in rats treated with methysergide (5 mg/Kg, i.v), an inespecific serotonergic antagonist. In anesthetized and ventilated animals, PTPP lowered the DBP and the HR in a significative manner. However these effects were completely abolished after bilateral cervical vagotomy. The PTPP relaxed phenylephrine or KCl 80 mM pre-contracted rat aortic artery rings both with intact or denuded endothelium. This response was independent of the presence of a functional vascular endothelium. These results taken together, suggest that the hypotension and bradicardia observed after PTPP is probably due to direct cardiac activation and as a result of a direct spasmolytic effect.

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Published

2011-12-15

How to Cite

Araújo-Júnior, J. X. de, J. X. de Araújo-Júnior, Êurica A. N. Ribeiro, S. A. S. da Silva, C. D. F. da Costa, M. Suzana Alexandre-Moreira, and B. V. O. Santos. “CARDIOVASCULAR EFFECTS OF TWO AMIDES (PIPERINE AND PIPERDARDINE)ISOLATED FROM PIPER TUBERCULATUM JACQ”. Emirates Journal of Food and Agriculture, vol. 23, no. 3, Dec. 2011, pp. 265-74, https://ejfa.me/index.php/journal/article/view/1145.

Issue

Vol 23, Issue 3, 2011

Section

Regular Articles