Relationship Among Antibiotic Residues And Antibacterial Activity Of The Endemic Spurge Honey (Euphorbia Resinifera O. Berg) From Morocco
DOI:
https://doi.org/10.9755/ejfa.2020.v32.i11.2190Abstract
Antibiotic-resistant bacteria continue to be of major health concern worldwide. In recent years, several reports and scientific articles claim the contamination of honey by antibiotics, detectable concentrations of antibiotic residues in honey are illegal. They, may cause hypersensitivity or resistance to drug therapy in humans, and are perceived by consumers as undesirable. In this sense, the purpose of this work was to examine the antibacterial activity of the Euphorbia resinifera (E. resinifera) honey against Escherichia coli and Staphylococcus aureus in vitro using the well-agar diffusion assay followed by dilution range to obtain more precise minimum inhibitory concentration values. The second aim is to evaluate the presence of antibiotics in honey using a screening test: Evidence InvestigatorTM, an immuno-enzymatic method for detection of 27 antibiotic residues followed by a liquid chromatography-tandem mass spectrometry (LC-MS/MS) for confirmation of suspect samples; in order to assess the relationship between the presence of antibiotic residues and the antibacterial activity of honey. In this study, a total of 37 E. resinifera honey samples were analyzed. The results show that all samples of honey inhibited the growth of bacteria at the dilutions at 50% (v/v); the highest inhibition zone (25.98 ± 0.11 mm) was recorded from sample 5 for Staphylococcus aureus and (13.84 ± 1.10 mm) in sample 17 for Escherichia coli and that 50% (v/v) dilutions showed significant antibacterial effect compared to other dilutions (6.25, 12.5, 25% (v/v)). In all samples, there were no antibiotic residues detected except for one showing the detection of Trimethoprim at 6.48 µg kg-1. Our research is one of the first studies that relate the he relationship between the presence of antibiotic residues and the antibacterial activity of Euphorbia resinifera honey and showed that the antibacterial activity of honey might be due to the high osmotic nature, a low pH, its content of phenolic compounds and hydrogen peroxide and also to its content of methylglyoxal.
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References
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Gaudin, V. 2017. Advances in biosensor development for the screening of antibiotic residues in food products of animal origin – A comprehensive review. Biosens. Bioelectron. 90, 363–377. https://doi.org/10.1016/j.bios.2016.12.005
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Jin, Y., J. Zhang, W. Zhao, W. Zhang, L. Wang, J. Zhou AND Y. Li. 2017. Development and validation of a multiclass method for the quantification of veterinary drug residues in honey and royal jelly by liquid chromatography–tandem mass spectrometry. Food Chem. 221, 1298–1307. https://doi.org/10.1016/j.foodchem.2016.11.026
Kaufmann, A., S. Roth, B. Ryser, M. Widmer and D. Guggisberg. 2002. Quantitative LC/MS-MS determination of sulfonamides and some other antibiotics in honey. J. AOAC Int. 85, 853–860. https://doi.org/10.1093/jaoac/85.4.853
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Published
2020-11-08
How to Cite
Benjamaa, R., A. Moujanni, A. Terrab, R. Eddoha, M. Benbachir, A. Moujahid, B. Nasser, S. Darkaoui, N. Zyate, A. Talmi, and A. . K. Essamadi. “Relationship Among Antibiotic Residues And Antibacterial Activity Of The Endemic Spurge Honey (Euphorbia Resinifera O. Berg) From Morocco”. Emirates Journal of Food and Agriculture, vol. 32, no. 11, Nov. 2020, pp. 795-07, doi:10.9755/ejfa.2020.v32.i11.2190.
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Research Article
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