A New Isoflavone from Lomariopsis guineensis (Underw.) Alston

Naser F. Al-Tannak; Abdullah Al Ali; Eman Santali; C. J. Clements; A. I. Gray; J. O. Igoli

doi:10.9755/ejfa.2023.v35.i4.3034

Authors

Naser F. Al-Tannak Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Jamal Abdul Nasser St, Kuwait
Abdullah Al Ali In Vitro toxicology group, Institute of Life Science, Swansea University, Medical School, Singleton Park Campus.
Eman Santali 3Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
C. J. Clements Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
A. I. Gray Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
J. O. Igoli Department of Chemistry, University of Agriculture (Joseph Sarwuan Tarka University) Makurdi. PMB 2373, Benue State, Nigeria

DOI:

https://doi.org/10.9755/ejfa.2023.v35.i4.3034

Abstract

Aim/background: Lomariopsis guineensis (Underw.) Alston is an epiphytic climbing fern. It is widely distributed in Africa where it is also used in traditional medicine and as food. There are no previous reports of any constituents of the plant, hence this study to isolate any phytoconstituents. Method: The ethyl acetate extract of the leaves was subjected to column chromatography and isolated constituents were characterized using nuclear magnetic resonance and mass spectrometry. Results: Three compounds were isolated and identified as cycloartenol, pheophytin A and a new isoflavone (5, 7-dihydroxy-4′ methoxy-6,8-dimethylisoflavone). Conclusion: Three phytochemicals including a new isoflavone are reported from the plant for the first time.

Keywords: Isoflavone; Lomariopsis guineensis; pheophytin A; cycloartenol; antitrypanosomal assay