Uric acid–reducing efficacy of Plectranthus amboinicus (Lour.) Spreng in mice with potassium oxonate-induced hyperuricemia

Chih-Chiang Wang; Chun Chen; Chih-Wei Chang; Po-Yen Chiu; Fu-An Chen

doi:10.9755/ejfa.2023.3188

Authors

Chih-Chiang Wang Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 802 and School of Medicine, National Defense Medical Center, Taipei 114, Taiwan
Chun Chen School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Chih-Wei Chang Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan
Po-Yen Chiu Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan
Fu-An Chen Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan

DOI:

https://doi.org/10.9755/ejfa.2023.3188

Abstract

Plectranthus amboinicus (Lour.) Spreng is a type of Lamiaceae perennial herb that is widely used in folk treatments for respiratory and skin diseases. Notably, research on the hypouricemic effect of P. amboinicus is limited. This study investigated the uric acid–reducing efficacy of P. amboinicus in mice with potassium oxonate-induced hyperuricemia by performing an in vitro xanthine-oxidase-inhibition-activity-guided test of P. amboinicus extract (PAE) and its fractions. The ethyl acetate fraction (EAF) of PAE exhibited optimal efficacy in terms of the phenolic content, DPPH scavenging activity, and xanthine oxidase inhibition. We further demonstrated the uric acid–reducing activity of EAF in a mouse model of potassium bromate–induced hyperuricemia. The results can serve as a useful preclinical reference for researching the gout prevention effects of functional foods.

Keywords: Plectranthus amboinicus (Lour.) Spreng, hyperuricemia, uric acid–reducing activity