EVALUATION OF OIL-RESIN ACTIVITY OF COPAIFERA SP. ON GASTRIC EMPTYING IN RATTUS NOVERGICUS

Camila M. A. Vilanova; Sahâmia M. Ribeiro; Rodolfo C. S. Machado; Salatiel M. Vieira; Sidney G. de Lima; Paulo H. M. Nunes; Maria C. C. Martins

doi:10.9755/ejfa.v25i5.15510

Authors

Camila M. A. Vilanova Acadêmicos de Medicina, Universidade Federal do Piauí (UFPI), Teresina-PI, Brazil
Sahâmia M. Ribeiro 1 Acadêmicos de Medicina, Universidade Federal do Piauí (UFPI), Teresina-PI, Brazil
Rodolfo C. S. Machado camilamariavilanova@gmail.com
Salatiel M. Vieira 1 Acadêmicos de Medicina, Universidade Federal do Piauí (UFPI), Teresina-PI, Brazil
Sidney G. de Lima camilamariavilanova@gmail.com
Paulo H. M. Nunes Departamento de Química-CCN, Universidade Federal do Piauí (UFPI), Teresina-PI, Brazil
Maria C. C. Martins Departamento de Química-CCN, Universidade Federal do Piauí (UFPI), Teresina-PI, Brazil

DOI:

https://doi.org/10.9755/ejfa.v25i5.15510

Keywords:

Copaifera sp., Gastric emptying, Rattus novergicus

Abstract

The Copaiba oil-resin (Copaifera sp.) is widely used in folk medicine, especially as a healing, antiinflammatory, antiseptic, to treat ulcers and skin diseases. Increased gastric emptying was observed with oilresin of Copaifera langsdorfii, highlighting those others species from the genus of Copaifera can act over the gastrointestinal tract. This study evaluated the activity of the Copaifera sp oil-resin on gastric emptying in Rattus novergicus. Eighteen male rats were fasted for 24h and orally received Tween-80 and Copaiba oil-resin 100 and 200 mg/kg; one hour later they all received phenol red (PR) 0.5 mg/mL. Then, the parts of gastrointestinal tract (stomach and intestine) were analyzed. The results showed that Copaifera sp oil-resin at 200 mg/kg increased the gastric emptying in Rattus novergicus.