TY - JOUR AU - Ernesto, Ramírez-Orozco Ricardo AU - Alejandra, Pedroza-García Karina AU - David, Masuoka AU - Alberto, Camacho-Morales AU - Anahí, Álvarez-Miramontes Silvia AU - Alejandro, Martínez-Miranda Christian PY - 2021/04/25 Y2 - 2024/03/28 TI - Putative role of N-Arachidonoyl glycine (NAGly) Acute hyperphagia in BALB/c mice JF - Emirates Journal of Food and Agriculture JA - Emir J Food Agric VL - 33 IS - 3 SE - Research Article DO - 10.9755/ejfa.2021.v33.i3.2657 UR - https://ejfa.me/index.php/journal/article/view/2657 SP - 245-252 AB - <p><strong>Introduction: </strong>Obesity is a pandemic problem associated to development of chronic degenerative diseases. N-arachidonylglycine (NAGly) is speculated to participate in pain regulation, immunity and insulin secretion; some N-acyl amino acids induce hyperphagia; in light of this, NAGly metabolic functions related to energy homeostasis has not been clarified yet. We aim to elucidate the effect of NAGly administration on weight gain, food intake, diet preferences and inflammatory profile changes in a murine model. <strong>Methods: </strong>8-week-old BALB/c mice (n=78) were allocated into 4 groups for either sex: control, vector, NAGly-LD (1nM) and NAGly-HD (10nM). NAGly was subcutaneous administered 5 consecutive days for 3 weeks. Mice were exposed to standard diet (SD), high-fat diet (HFD) and high-sugar diet (HSD) simultaneously; weight gain, food intake and diet preferences were evaluated for 21-days. Finally, cytokines were analyzed by enzyme-linked immunosorbent assay (ELISA). <strong>Results: </strong>final weight gain was found higher in those following NAGly [LD: 21.6±1.1 g and HD: 21.4±2.1 g, (p=0.001)]. NAGly groups consumed more food in the first days; NAGly groups consumed more HFD [5.06±1.60; (p=0.001)] and HSD [1.10±0.69; (p=0.001)]. <strong>Conclusion: </strong>Our data propose that subcutaneous NAGly promotes acute hyperphagia events. We propose that NAGly might play a role related to the hunger-satiety circuit.</p> ER -