TY - JOUR AU - Abdullah, Saqib Saleem AU - Masood, Saima AU - Masood, Saima AU - Zaneb, Hafsa AU - Rabban, Imtiaz AU - Akba, Jamil AU - Hussain Kuthu, Zulfiqar PY - 2022/07/14 Y2 - 2024/03/29 TI - Effects of Copper nanoparticle supplementation on growth, intestinal morphology and antioxidant status in broilers exposed to cyclic cold stress JF - Emirates Journal of Food and Agriculture JA - Emir J Food Agric VL - 34 IS - 5 SE - Research Article DO - 10.9755/ejfa.2022.v34.i5.2862 UR - https://ejfa.me/index.php/journal/article/view/2862 SP - AB - <p>The purpose of this research was to determine the effects of copper nanoparticles (CuNP) supplementation on growth performance, intestinal<br>morphology, intraepithelial lymphocytes (IELs), goblet cell (GC) count, stress hormones and oxidant/antioxidant balance of broilers exposed<br>to cold stress. One day old broiler chickens (n=400) were allocated into five different groups and were raised under standard conditions<br>until the 21st day. The five groups were designated as thermo-neutral (TN reared in 26°C), cold stress (CS raised under 13°C±2°C for<br>8 hours/day from d 22- d 35), CS5 (CS+ 5mg/kg diet CuNP), CS10 (CS+10mg/kg diet CuNP) and CS15 (CS+15mg/kg diet CuNP). On<br>35th day, 16 birds per group were selected randomly for blood collection and were then humanely sacrificed for tissue sample collection.<br>CS group had a reduced (P&lt;0.05) body weight (BW), villus surface area (VSA), villus height to crypt depth ratio (VH: CD) but had a<br>higher (P&lt;0.05) feed conversion ratio (FCR), goblet cell count, serum corticosterone and malondialdehyde (MDA) levels than the TN<br>group. Inclusion of CuNP in diet linearly increased (P&lt;0.05) BW, VH, VW, CD, VSA and GC count in jejunum and ileum. Conversely,<br>MDA and corticosterone hormone levels and FCR, decreased linearly (P&lt;0.05) with CuNP supplementation. In conclusion, during cold<br>stress conditions, CuNP is a valuable feed additive in broilers with positive effects on growth performance and intestinal morphology</p> ER -